Effect of sugammadex on chest radiographic abnormality in the early postoperative period after video-assisted thoracoscopic lobectomy

Dong Kyu Lee, Sung Wook Kang, Hyun Koo Kim, Hyo Sung Kim, Heezoo Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background/aim: Sugammadex, which offsets the effects of neuromuscular blocking agents (NMBs), has advantages over traditional reversal agents like pyridostigmine, as it enables fast and reliable recovery from neuromuscular blockade. This study compared the incidence of early postoperative chest radiographic abnormalities (CRA) between sugammadex (group S) and pyridostigmine (group P) following video-assisted thoracoscopic (VAT) lobectomy for lung cancer. Materials and methods: We performed a retrospective cohort analysis by reviewing the medical records of patients who underwent VAT lobectomy at a single university medical center. We defined the early postoperative CRA as a characteristic appearance on chest radiograph up to 2 days after surgery. Arterial blood gas analysis (ABGA), surgical time, anaesthesia time, extubation time, and the total dose of rocuronium were analysed. Postoperative nausea and vomiting (PONV) and pain scores were observed until 2 days after surgery. Results: A total of 257 patients underwent VAT lobectomy during the study period; 159 were included in the final analysis. Ninety patients received sugammadex while 69 received pyridostigmine. The incidence of early postoperative atelectasis was significantly lower in group S than in group P (26.7%, 95% CI: 17.5%‒35.8% and 43.5%, 95% CI: 31.8%‒55.2%, respectively, P = 0.013). The median dose of rocuronium was higher in group S than in group P (120 mg vs. 90 mg, P < 0.001). ABGA, extubation time, and PONV were similar in both groups. Conclusion: Sugammadex decreased the incidence of CRA in the early postoperative period despite higher NMB consumption.

Original languageEnglish
Pages (from-to)1236-1246
Number of pages11
JournalTurkish Journal of Medical Sciences
Volume50
Issue number5
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-forprofit sectors. The authors have read the STROBE statement – a checklist of items, and the manuscript was both written and revised according to the STROBE statement checklist of items. There is the registration of the Human Research Ethics Committee-Institutional Review Board of Korea University Guro Hospital Clinical Trial Centre, Reference No. (KUGH15280-001), approved on 10 December 2015.

Publisher Copyright:
© TÜBİTAK.

Keywords

  • Anticholinesterases
  • Postoperative complications
  • Sugammadex
  • Thoracic radiography
  • Video-assisted thoracic surgery

ASJC Scopus subject areas

  • General Medicine

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