Abstract
The effects of hesperetin and naringenin on NF-κB activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced NF-κB activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced NF-κB activation in NIH3T3γ1 cells. In addition, the DNA binding activity of SP-1 was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced NF-κB activation could occur via Akt-GSK-3 pathway without IκBα degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of NF-κB activation.
Original language | English |
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Pages (from-to) | 244-249 |
Number of pages | 6 |
Journal | Korean Journal of Pharmacognosy |
Volume | 35 |
Issue number | 3 |
Publication status | Published - 2004 Sept |
Externally published | Yes |
Keywords
- Akt
- Flavonoid
- GSK-3
- Hesperetin
- IκBα
- NF-κB
- Naringenin
- v-Src
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery