Effect of various shaped magnesium hydroxide particles on mechanical and biological properties of poly(lactic-co-glycolic acid) composites

Hye Jung Jang; Sung Bin Park; Tarek M. Bedair; Min Kyu Oh; Dong June Ahn; Wooram Park; Yoon Ki Joung; Dong Keun Han

doi:10.1016/j.jiec.2017.10.032

Effect of various shaped magnesium hydroxide particles on mechanical and biological properties of poly(lactic-co-glycolic acid) composites

Hye Jung Jang, Sung Bin Park, Tarek M. Bedair, Min Kyu Oh, Dong June Ahn, Wooram Park, Yoon Ki Joung, Dong Keun Han

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Five different shapes of magnesium hydroxide (Mg(OH)₂) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)₂ particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)₂ particles. Among them, the fiber shape of Mg(OH)₂ provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.

Original language	English
Pages (from-to)	266-276
Number of pages	11
Journal	Journal of Industrial and Engineering Chemistry
Volume	59
DOIs	https://doi.org/10.1016/j.jiec.2017.10.032
Publication status	Published - 2018 Mar 25

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program ( 2017R1A2B3011121 ), Bio & Medical Technology Development Program ( 2014M3A9D3033887 ), and the Next Generation Medical Device Platform Program (2015M3A9E2028580): through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Core Materials Technology Development Program (10048019) founded by Ministry of Trade, Industry and Energy (MOTIE), Republic of Korea.

Publisher Copyright:
© 2017 The Korean Society of Industrial and Engineering Chemistry

Keywords

Anti-bacterial activity
Anti-inflammation effect
Magnesium hydroxide
Mechanical property
Poly(lactic-co-glycolic acid) composites

ASJC Scopus subject areas

Chemical Engineering(all)

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10.1016/j.jiec.2017.10.032

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title = "Effect of various shaped magnesium hydroxide particles on mechanical and biological properties of poly(lactic-co-glycolic acid) composites",

abstract = "Five different shapes of magnesium hydroxide (Mg(OH)2) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)2 particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)2 particles. Among them, the fiber shape of Mg(OH)2 provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.",

keywords = "Anti-bacterial activity, Anti-inflammation effect, Magnesium hydroxide, Mechanical property, Poly(lactic-co-glycolic acid) composites",

author = "Jang, {Hye Jung} and Park, {Sung Bin} and Bedair, {Tarek M.} and Oh, {Min Kyu} and Ahn, {Dong June} and Wooram Park and Joung, {Yoon Ki} and Han, {Dong Keun}",

note = "Funding Information: This work was supported by the Basic Science Research Program ( 2017R1A2B3011121 ), Bio & Medical Technology Development Program ( 2014M3A9D3033887 ), and the Next Generation Medical Device Platform Program (2015M3A9E2028580): through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Core Materials Technology Development Program (10048019) founded by Ministry of Trade, Industry and Energy (MOTIE), Republic of Korea. Publisher Copyright: {\textcopyright} 2017 The Korean Society of Industrial and Engineering Chemistry",

year = "2018",

month = mar,

day = "25",

doi = "10.1016/j.jiec.2017.10.032",

language = "English",

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journal = "Journal of Industrial and Engineering Chemistry",

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AU - Jang, Hye Jung

AU - Park, Sung Bin

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AU - Oh, Min Kyu

AU - Ahn, Dong June

AU - Park, Wooram

AU - Joung, Yoon Ki

AU - Han, Dong Keun

N1 - Funding Information: This work was supported by the Basic Science Research Program ( 2017R1A2B3011121 ), Bio & Medical Technology Development Program ( 2014M3A9D3033887 ), and the Next Generation Medical Device Platform Program (2015M3A9E2028580): through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Core Materials Technology Development Program (10048019) founded by Ministry of Trade, Industry and Energy (MOTIE), Republic of Korea. Publisher Copyright: © 2017 The Korean Society of Industrial and Engineering Chemistry

PY - 2018/3/25

Y1 - 2018/3/25

N2 - Five different shapes of magnesium hydroxide (Mg(OH)2) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)2 particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)2 particles. Among them, the fiber shape of Mg(OH)2 provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.

AB - Five different shapes of magnesium hydroxide (Mg(OH)2) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)2 particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)2 particles. Among them, the fiber shape of Mg(OH)2 provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.

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KW - Anti-inflammation effect

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Effect of various shaped magnesium hydroxide particles on mechanical and biological properties of poly(lactic-co-glycolic acid) composites

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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