Five different shapes of magnesium hydroxide (Mg(OH)2) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)2 particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)2 particles. Among them, the fiber shape of Mg(OH)2 provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.
Bibliographical noteFunding Information:
This work was supported by the Basic Science Research Program ( 2017R1A2B3011121 ), Bio & Medical Technology Development Program ( 2014M3A9D3033887 ), and the Next Generation Medical Device Platform Program (2015M3A9E2028580): through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT) and Core Materials Technology Development Program (10048019) founded by Ministry of Trade, Industry and Energy (MOTIE), Republic of Korea.
© 2017 The Korean Society of Industrial and Engineering Chemistry
- Anti-bacterial activity
- Anti-inflammation effect
- Magnesium hydroxide
- Mechanical property
- Poly(lactic-co-glycolic acid) composites
ASJC Scopus subject areas
- Chemical Engineering(all)