Effective contamination control strategies facilitating axenic cultivation of Haematococcus pluvialis: Risks and challenges

Byung Sun Yu, So Young Lee, Sang Jun Sim

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


With industrialization, anthropogenic mishandlings have resulted in the discharge of abundant amount of CO2 into the atmosphere. This has triggered an unnatural warming that has dramatically increased the Earth's temperature in a short duration. This problem can be addressed by the biological conversion of CO2; several studies have been conducted using H. pluvialis culture that produces high value-added materials, such as astaxanthin and omega-3 fatty acids. However, although H. pluvialis has a high market value, the market size is quite small. Because H. pluvialis cells are susceptible to contamination due to its slow growth rate, hence large-scale culture of H. pluvialis without reliable contamination control strategies poses significant risks. This review comprehensively discusses the contamination that occurs during the culturing of H. pluvialis in various culture systems under different culture conditions. The review also discusses the strategies in controlling the biotic contaminants, such as bacteria and fungi.

Original languageEnglish
Article number126289
JournalBioresource technology
Publication statusPublished - 2022 Jan

Bibliographical note

Funding Information:
This work was supported by “Carbon to X Project” (#2020M3H7A1098295), the National Research Foundation (NRF) funded by the Ministry of Science and ICT, Republic of Korea, a grant (#NRF-2019R1A2C3009821/2020R1A5A1018052) from the National Research Foundation of Korea (NRF), and the Commercializations Promotion Agency for R&D Outcomes (COMPA) grant funded by the Korea government (MSIT) (No. 2021B100).

Publisher Copyright:
© 2021 Elsevier Ltd


  • Algicidal microorganism
  • Astaxanthin
  • Contamination
  • Culture condition
  • Culture system
  • Decontamination strategy
  • Haematococcus pluvialis

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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