Abstract
Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 353 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Dec 15 |
Bibliographical note
Funding Information:This work is supported by grants R01-2000-000-00165-0 from the basic research program of the Korea Science and Engineering Foundation.
Keywords
- Fucoidin
- Neuroprotection
- P-selectin
- Perinatal hypoxic-ischemic encephalopathy
ASJC Scopus subject areas
- General Neuroscience