Effectiveness of topical chia seed oil on pruritus of end-stage renal disease (ESRD) patients and healthy volunteers

Se Kyoo Jeong, Hyun Jung Park, Byeong Deog Park, Il Hwan Kim

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


Background: Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms. Objective: In order to investigate the possible beneficial effects of topical n-3 fatty acid, oils extracted from chia (Salvia hispanica) seed were formulated into topical products, the effects of which were measured. Methods: Five healthy volunteers having xerotic pruritus symptoms and 5 patients with pruritus caused by either ESRD or diabetes were involved in this study. A topical formulation containing 4% chia seed oils were applied for an 8-week duration. Subjective itching symptoms were assessed on a 6-point scale, as were other skin functions, namely transepidermal water loss and skin capacitance. Results: After the 8 weeks of application, significant improvements in skin hydration, lichen simplex chronicus, and prurigo nodularis were observed in all patients. A similar improvement was also observed among healthy volunteers with xerotic pruritus. Improvement of epidermal permeability barrier function and skin hydration, represented by trans-epidermal water loss and skin capacitance, respectively, were also observed. No adverse effects were observed in all the tested patients and volunteers. Conclusion: Chia seed oil can be used as an adjuvant moisturizing agent for pruritic skin, including that of ESRD patients.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalAnnals of Dermatology
Issue number2
Publication statusPublished - 2010 May
Externally publishedYes


  • Alpha-linolenic acid
  • Chia seed oil
  • End-stage renal failure
  • Omega-3 fatty acids
  • Pruritus

ASJC Scopus subject areas

  • Dermatology


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