Abstract
Deer bone extract has the potential to relieve the discomfort or the articular cartilaginous damage associated with osteoarthritic (OA) and may be useful as a natural supplement for OA treatment without serious side effects. We analyzed the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced OA rats. Increases in the levels of serum pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α were significantly inhibited by the administration of deer bone extract (p < 0.05). Decreases in the expression of collagen type II (COL2) and tissue inhibitors of metalloproteinases (TIMPs) mRNAs in the cartilage were significantly inhibited by deer bone extract treatment (p < 0.05). The deer bone extract significantly suppressed the expression of matrix metalloproteinases (MMPs) mRNAs in the cartilage. The deer bone extract induced the up-regulation of COL2 and TIMP mRNAs and the down-regulation of MMP mRNAs by suppressing the expression of pro-inflammatory cytokine mRNAs.
| Original language | English |
|---|---|
| Pages (from-to) | 1703-1709 |
| Number of pages | 7 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 78 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2014 |
Bibliographical note
Publisher Copyright:© 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
Keywords
- Deer bone extract
- Matrix metalloproteinase
- Osteoarthritis
- Proinflammatory cytokines
- Tissue inhibitors of metalloproteinases
ASJC Scopus subject areas
- General Medicine