Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats

Hak Jin Moon, Bong Soo Lim, Dae Il Lee, Min Sook Ye, Giseog Lee, Byung Il Min, Hyunsu Bae, Heung Sik Na, Sun Kwang Kim

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (α-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma β-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalJournal of Physiological Sciences
Issue number2
Publication statusPublished - 2014 Mar


  • Cold allodynia
  • Electroacupuncture
  • Endogenous opioid
  • Noradrenergic
  • Oxaliplatin

ASJC Scopus subject areas

  • Physiology


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