Effects of Fermented Ginseng extracts on tumor metastasis in Mice

Dong Zhou Kang, Dan Liu, Seon Yoong Jo, Tae Bong Kang, Jin Moo Lee, Hyung Joo Suh, Ae jung Kim, Taek Joon Yoon

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.

Original languageEnglish
Pages (from-to)1559-1565
Number of pages7
JournalFood Science and Biotechnology
Issue number6
Publication statusPublished - 2010


  • Cytokine
  • Fermented-ginseng
  • Innate immunity
  • Mucosal immunity
  • Tumor metastasis

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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