Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice

Hee Ho Song; Ki Bae Hong; Sunhoo Kim; Byung Yong Kim; Shin Hyung Shik; Hyung Joo Suh; Yejin Ahn

doi:10.1016/j.jff.2023.105554

Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice

Hee Ho Song, Ki Bae Hong, Sunhoo Kim, Byung Yong Kim, Shin Hyung Shik, Hyung Joo Suh, Yejin Ahn

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Collagen is a popular supplement and an essential protein associated with the preservation of skin firmness. Here, effects of fish collagen administration on skin aging symptoms and gut microbiota composition were investigated using ultraviolet (UV) B-irradiated SKH-1 hairless mice. Eight weeks of high-dose fish collagen administration significantly improved skin moisture and wrinkle parameters. Histopathological and molecular analyses revealed that fish collagen affected reactive oxygen species (ROS) and cytokine production, and the expression of genes related to extracellular matrix (ECM) homeostasis and significantly improved the epidermal thickness and collagen content. Additionally, collagen increased intracellular signaling process-related transforming growth fac-tor-beta (TGF-β) and TGF-β receptor levels and Smad phosphorylation. Furthermore, collagen administration significantly changed the abundance of Limosilactobacillus, Akkermansia, and Ruminococcus at the genus level. Collectively, fish collagen regulated ECM homeostasis, ROS and cytokine production, and the gut microbiota composition to increase skin health, including the reduction of skin wrinkles.

Original language	English
Article number	105554
Journal	Journal of Functional Foods
Volume	105
DOIs	https://doi.org/10.1016/j.jff.2023.105554
Publication status	Published - 2023 Jun

Bibliographical note

Funding Information:
This research was supported by CKD Healthcare (Seoul, South Korea), grant number Q2106751. The animal study protocol was approved by the Institutional Animal Care and Use Committee of Korea University (protocol code KUIACUC-2021-0035 and approval date 04.21.2021).

Publisher Copyright:
© 2023 The Author(s)

Keywords

Fish collagen
Gut microbiota
Skin health
TGF-β/Smad signaling

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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Song, H. H., Hong, K. B., Kim, S., Kim, B. Y., Hyung Shik, S., Suh, H. J., & Ahn, Y. (2023). Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice. Journal of Functional Foods, 105, Article 105554. https://doi.org/10.1016/j.jff.2023.105554

Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice. / Song, Hee Ho; Hong, Ki Bae; Kim, Sunhoo et al.
In: Journal of Functional Foods, Vol. 105, 105554, 06.2023.

Research output: Contribution to journal › Article › peer-review

Song, HH, Hong, KB, Kim, S, Kim, BY, Hyung Shik, S, Suh, HJ & Ahn, Y 2023, 'Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice', Journal of Functional Foods, vol. 105, 105554. https://doi.org/10.1016/j.jff.2023.105554

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abstract = "Collagen is a popular supplement and an essential protein associated with the preservation of skin firmness. Here, effects of fish collagen administration on skin aging symptoms and gut microbiota composition were investigated using ultraviolet (UV) B-irradiated SKH-1 hairless mice. Eight weeks of high-dose fish collagen administration significantly improved skin moisture and wrinkle parameters. Histopathological and molecular analyses revealed that fish collagen affected reactive oxygen species (ROS) and cytokine production, and the expression of genes related to extracellular matrix (ECM) homeostasis and significantly improved the epidermal thickness and collagen content. Additionally, collagen increased intracellular signaling process-related transforming growth fac-tor-beta (TGF-β) and TGF-β receptor levels and Smad phosphorylation. Furthermore, collagen administration significantly changed the abundance of Limosilactobacillus, Akkermansia, and Ruminococcus at the genus level. Collectively, fish collagen regulated ECM homeostasis, ROS and cytokine production, and the gut microbiota composition to increase skin health, including the reduction of skin wrinkles.",

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N2 - Collagen is a popular supplement and an essential protein associated with the preservation of skin firmness. Here, effects of fish collagen administration on skin aging symptoms and gut microbiota composition were investigated using ultraviolet (UV) B-irradiated SKH-1 hairless mice. Eight weeks of high-dose fish collagen administration significantly improved skin moisture and wrinkle parameters. Histopathological and molecular analyses revealed that fish collagen affected reactive oxygen species (ROS) and cytokine production, and the expression of genes related to extracellular matrix (ECM) homeostasis and significantly improved the epidermal thickness and collagen content. Additionally, collagen increased intracellular signaling process-related transforming growth fac-tor-beta (TGF-β) and TGF-β receptor levels and Smad phosphorylation. Furthermore, collagen administration significantly changed the abundance of Limosilactobacillus, Akkermansia, and Ruminococcus at the genus level. Collectively, fish collagen regulated ECM homeostasis, ROS and cytokine production, and the gut microbiota composition to increase skin health, including the reduction of skin wrinkles.

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Effects of fish collagen on hairless mice skin photoaging induced by ultraviolet irradiation via regulation of the TGF- β signaling pathway: Anti-photoaging effect of fish collagen in UVB-induced hairless mice

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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