Effects of hyaluronic acid and deproteinized bovine bone mineral with 10% collagen for ridge preservation in compromised extraction sockets

Jun Beom Lee; Seoyoon Chu; Heithem Ben Amara; Hyun Young Song; Min Jung Son; Jungwon Lee; Hae Young Kim; Ki Tae Koo; In Chul Rhyu

doi:10.1002/JPER.20-0832

Effects of hyaluronic acid and deproteinized bovine bone mineral with 10% collagen for ridge preservation in compromised extraction sockets

Jun Beom Lee, Seoyoon Chu, Heithem Ben Amara, Hyun Young Song, Min Jung Son, Jungwon Lee, Hae Young Kim, Ki Tae Koo, In Chul Rhyu

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets. Methods: Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted, and then combined endodontic periodontal lesion was induced in the remaining mesial roots. After 4 months, the mesial roots were extracted and the following four treatments were randomly performed: Absorbable collagen sponge (ACS), ACS soaked with HA (ACS+HA), ridge preservation with DBBM-C covered with a collagen membrane (RP), ridge preservation with DBBM-C mixed with HA and covered with a collagen membrane (RP+HA). Animals were sacrificed at 1 and 3 months following treatment. Ridge dimensional changes and bone formation were examined using microcomputed tomography, histology, and histomorphometry. Results: At 1 month, ridge width was significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups, while the highest proportion of mineralized bone was observed in ACS+HA group. At 3 months, ridge width remained significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups. ACS+HA and RP+HA treatments featured the highest proportion of mineralized bone and bone volume density compared with the other groups. No statistical difference was observed between ACS+HA and RP+HA treatments. Conclusions: Ridge preservation with the mixture DBBM-C/HA prevented dimensional shrinkage and improved bone formation in compromised extraction sockets at 1 and 3 months.

Original language	English
Pages (from-to)	1564-1575
Number of pages	12
Journal	Journal of Periodontology
Volume	92
Issue number	11
DOIs	https://doi.org/10.1002/JPER.20-0832
Publication status	Published - 2021 Nov

Bibliographical note

Funding Information:
The project (17‐243) was supported by a grant from the Osteology Foundation, Switzerland. The authors report no conflicts of interest related to this study.

Publisher Copyright:
© 2021 American Academy of Periodontology

Keywords

alveolar bone grafting
bone regeneration
growth factors
hyaluronic acid
tooth extraction
tooth socket

ASJC Scopus subject areas

Periodontics

Access to Document

10.1002/JPER.20-0832

Cite this

@article{0c2ccb90d1154ea59e590e37c2eb7f56,

title = "Effects of hyaluronic acid and deproteinized bovine bone mineral with 10% collagen for ridge preservation in compromised extraction sockets",

abstract = "Background: The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets. Methods: Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted, and then combined endodontic periodontal lesion was induced in the remaining mesial roots. After 4 months, the mesial roots were extracted and the following four treatments were randomly performed: Absorbable collagen sponge (ACS), ACS soaked with HA (ACS+HA), ridge preservation with DBBM-C covered with a collagen membrane (RP), ridge preservation with DBBM-C mixed with HA and covered with a collagen membrane (RP+HA). Animals were sacrificed at 1 and 3 months following treatment. Ridge dimensional changes and bone formation were examined using microcomputed tomography, histology, and histomorphometry. Results: At 1 month, ridge width was significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups, while the highest proportion of mineralized bone was observed in ACS+HA group. At 3 months, ridge width remained significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups. ACS+HA and RP+HA treatments featured the highest proportion of mineralized bone and bone volume density compared with the other groups. No statistical difference was observed between ACS+HA and RP+HA treatments. Conclusions: Ridge preservation with the mixture DBBM-C/HA prevented dimensional shrinkage and improved bone formation in compromised extraction sockets at 1 and 3 months.",

keywords = "alveolar bone grafting, bone regeneration, growth factors, hyaluronic acid, tooth extraction, tooth socket",

author = "Lee, {Jun Beom} and Seoyoon Chu and {Ben Amara}, Heithem and Song, {Hyun Young} and Son, {Min Jung} and Jungwon Lee and Kim, {Hae Young} and Koo, {Ki Tae} and Rhyu, {In Chul}",

note = "Funding Information: The project (17‐243) was supported by a grant from the Osteology Foundation, Switzerland. The authors report no conflicts of interest related to this study. Publisher Copyright: {\textcopyright} 2021 American Academy of Periodontology",

year = "2021",

month = nov,

doi = "10.1002/JPER.20-0832",

language = "English",

volume = "92",

pages = "1564--1575",

journal = "Journal of Periodontology",

issn = "0022-3492",

publisher = "John Wiley & Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Effects of hyaluronic acid and deproteinized bovine bone mineral with 10% collagen for ridge preservation in compromised extraction sockets

AU - Lee, Jun Beom

AU - Chu, Seoyoon

AU - Ben Amara, Heithem

AU - Song, Hyun Young

AU - Son, Min Jung

AU - Lee, Jungwon

AU - Kim, Hae Young

AU - Koo, Ki Tae

AU - Rhyu, In Chul

N1 - Funding Information: The project (17‐243) was supported by a grant from the Osteology Foundation, Switzerland. The authors report no conflicts of interest related to this study. Publisher Copyright: © 2021 American Academy of Periodontology

PY - 2021/11

Y1 - 2021/11

N2 - Background: The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets. Methods: Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted, and then combined endodontic periodontal lesion was induced in the remaining mesial roots. After 4 months, the mesial roots were extracted and the following four treatments were randomly performed: Absorbable collagen sponge (ACS), ACS soaked with HA (ACS+HA), ridge preservation with DBBM-C covered with a collagen membrane (RP), ridge preservation with DBBM-C mixed with HA and covered with a collagen membrane (RP+HA). Animals were sacrificed at 1 and 3 months following treatment. Ridge dimensional changes and bone formation were examined using microcomputed tomography, histology, and histomorphometry. Results: At 1 month, ridge width was significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups, while the highest proportion of mineralized bone was observed in ACS+HA group. At 3 months, ridge width remained significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups. ACS+HA and RP+HA treatments featured the highest proportion of mineralized bone and bone volume density compared with the other groups. No statistical difference was observed between ACS+HA and RP+HA treatments. Conclusions: Ridge preservation with the mixture DBBM-C/HA prevented dimensional shrinkage and improved bone formation in compromised extraction sockets at 1 and 3 months.

AB - Background: The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets. Methods: Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted, and then combined endodontic periodontal lesion was induced in the remaining mesial roots. After 4 months, the mesial roots were extracted and the following four treatments were randomly performed: Absorbable collagen sponge (ACS), ACS soaked with HA (ACS+HA), ridge preservation with DBBM-C covered with a collagen membrane (RP), ridge preservation with DBBM-C mixed with HA and covered with a collagen membrane (RP+HA). Animals were sacrificed at 1 and 3 months following treatment. Ridge dimensional changes and bone formation were examined using microcomputed tomography, histology, and histomorphometry. Results: At 1 month, ridge width was significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups, while the highest proportion of mineralized bone was observed in ACS+HA group. At 3 months, ridge width remained significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups. ACS+HA and RP+HA treatments featured the highest proportion of mineralized bone and bone volume density compared with the other groups. No statistical difference was observed between ACS+HA and RP+HA treatments. Conclusions: Ridge preservation with the mixture DBBM-C/HA prevented dimensional shrinkage and improved bone formation in compromised extraction sockets at 1 and 3 months.

KW - alveolar bone grafting

KW - bone regeneration

KW - growth factors

KW - hyaluronic acid

KW - tooth extraction

KW - tooth socket

UR - http://www.scopus.com/inward/record.url?scp=85100579322&partnerID=8YFLogxK

U2 - 10.1002/JPER.20-0832

DO - 10.1002/JPER.20-0832

M3 - Article

C2 - 33484160

AN - SCOPUS:85100579322

SN - 0022-3492

VL - 92

SP - 1564

EP - 1575

JO - Journal of Periodontology

JF - Journal of Periodontology

IS - 11

ER -

Effects of hyaluronic acid and deproteinized bovine bone mineral with 10% collagen for ridge preservation in compromised extraction sockets

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this