Abstract
In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 816-819 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 79 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2015 |
Bibliographical note
Publisher Copyright:© 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
Keywords
- 3-hydroxy-3-methyl glutaryl coenzyme a (HMG-CoA) reductase
- Fatty acid synthase (FAS)
- HepG2 cells
- Hepatic lipid accumulation
- Korean red ginseng water extract (KRGE)
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry