Abstract
The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Japanese Archives of Internal Medicine |
| Volume | 41 |
| Issue number | 1 |
| Publication status | Published - 1994 |
| Externally published | Yes |
Keywords
- liver cirrhosis
- microsphere sampling method
- portal hypertension
- propranolol
- rat
ASJC Scopus subject areas
- Internal Medicine