Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL4

O. Nishida; S. H. Um; M. Tokubayashi; F. Kimura; Y. Takimoto; H. Yoshioka; R. Inoue; M. Murakami; T. Kita

Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL₄

O. Nishida^*
, S. H. Um
, M. Tokubayashi
, F. Kimura
, Y. Takimoto
, H. Yoshioka
, R. Inoue
, M. Murakami
, T. Kita

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Japanese Archives of Internal Medicine
Volume	41
Issue number	1
Publication status	Published - 1994
Externally published	Yes

Keywords

liver cirrhosis
microsphere sampling method
portal hypertension
propranolol
rat

ASJC Scopus subject areas

Internal Medicine

Cite this

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title = "Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL4",

abstract = "The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension",

keywords = "liver cirrhosis, microsphere sampling method, portal hypertension, propranolol, rat",

author = "O. Nishida and Um, \{S. H.\} and M. Tokubayashi and F. Kimura and Y. Takimoto and H. Yoshioka and R. Inoue and M. Murakami and T. Kita",

year = "1994",

language = "English",

volume = "41",

pages = "1--8",

journal = "Japanese Archives of Internal Medicine",

issn = "0021-4809",

publisher = "Kyoto Naika Hokan Kankoki",

number = "1",

}

TY - JOUR

T1 - Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL4

AU - Nishida, O.

AU - Um, S. H.

AU - Tokubayashi, M.

AU - Kimura, F.

AU - Takimoto, Y.

AU - Yoshioka, H.

AU - Inoue, R.

AU - Murakami, M.

AU - Kita, T.

PY - 1994

Y1 - 1994

N2 - The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension

AB - The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension

KW - liver cirrhosis

KW - microsphere sampling method

KW - portal hypertension

KW - propranolol

KW - rat

UR - https://www.scopus.com/pages/publications/0027931079

M3 - Article

AN - SCOPUS:0027931079

SN - 0021-4809

VL - 41

SP - 1

EP - 8

JO - Japanese Archives of Internal Medicine

JF - Japanese Archives of Internal Medicine

IS - 1

ER -

Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL₄

Abstract

Keywords

ASJC Scopus subject areas

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