Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention

Jae Suk Choi, Sung Kyu Jung, Min Hee Jeon, Jin Nam Moon, Woi Sook Moon, Yi Hwa Ji, In Soon Choi, Sang Wook Son

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9 Citations (Scopus)


To evaluate the potential hair growth–promoting activity and the expression of cell growth factors of Lycopersicon esculentum extracts, each 3% (w/w) of ethyl acetate extract (EAE), and supercritical CO2 extract (SCE) of L. esculentum and isolated lycopene Tween 80 solution (LTS) and test hair tonic (THT) containing LTS were applied on the dorsal skin of C57BL/6 mice, once a day for 4 weeks. At week 4, LTS and THT exhibited hair growth–promoting potential similar to that of 3% minoxidil as a positive control (PC). Further, in the LTS group, a significant increase of mRNA expression of vascular endothelial growth factor (VEGF), keratinocyte growth factor, and insulin-like growth factor-1 (IGF-1) was observed than PC, as well as the negative control (NC). In the THT group, increases in IGF-1 and decrease in VEGF and transforming growth factor-β expression were significant over the NC. In a histological examination in the THT group, the induction of anagen stage of hair follicles was faster than that of NC. In the Draize skin irritation study for THT, no observable edema or erythema was observed on all four sectors in the back skin after exposure for 24 or 72 h for any rabbit. Therefore, this study provides reasonable evidence that L. esculentum extracts promote hair growth and suggests that applications could be found in hair loss treatments without skin irritation at moderate doses.

Original languageEnglish
Pages (from-to)429-443
Number of pages15
JournalJournal of Cosmetic Science
Issue number6
Publication statusPublished - 2013 Nov 1

Bibliographical note

Funding Information:
This work was supported by a grant (no. S1079260) from the Ministry of Knowledge Economy, Republic of Korea. J.-S.C. and I.S.C. were also supported by the Global Healthcare Industry RIS Center from the Ministry of Knowledge Economy, Republic of Korea.

Publisher Copyright:
© 2013 Society of Cosmetic Chemists. All Rights Reserved.

ASJC Scopus subject areas

  • General Chemistry
  • Dermatology


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