Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Moon Soo Lee; Jae Won Yang; Young Hoon Ko; Changsu Han; Seung Hyun Kim; Min Soo Lee; Sook Haeng Joe; In Kwa Jung

doi:10.1007/s10578-007-0081-6

Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Moon Soo Lee, Jae Won Yang, Young Hoon Ko, Changsu Han, Seung Hyun Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.

Original language	English
Pages (from-to)	201-209
Number of pages	9
Journal	Child Psychiatry and Human Development
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s10578-007-0081-6
Publication status	Published - 2008 Jun
Externally published	Yes

Keywords

Attention deficit disorder with hyperactivity
Bupropion
Dehydroepiandrosterone sulfate
Methylphenidate

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10578-007-0081-6

Cite this

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abstract = "We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.",

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AU - Han, Changsu

AU - Kim, Seung Hyun

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

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Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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