Effects of Panax ginseng extract on human dermal fibroblast proliferation and collagen synthesis

Geum Young Lee, Kang Gyun Park, Sik Namgoong, Seung Kyu Han, Seong Ho Jeong, Eun Sang Dhong, Woo Kyung Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Current studies of Panax ginseng (or Korean ginseng) have demonstrated that it has various biological effects, including angiogenesis, immunostimulation, antimicrobial and anti-inflammatory effects. Therefore, we hypothesised that P. ginseng may also play an important role in wound healing. However, few studies have been conducted on the wound-healing effects of P. ginseng. Thus, the purpose of this in vitro pilot study was to determine the effects of P. ginseng on the activities of fibroblasts, which are key wound-healing cells. Cultured human dermal fibroblasts were treated with one of six concentrations of P. ginseng: 0, 1, 10 and 100 ng/ml and 1 and 10 μg/ml. Cell proliferation was determined 3 days post-treatment using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, and collagen synthesis was evaluated by the collagen type I carboxy-terminal propeptide method. Cell proliferation levels and collagen synthesis were compared among the groups. The 10 ng/ml to 1 μg/ml P. ginseng treatments significantly increased cell proliferation, and the 1 ng/ml to 1 μg/ml concentrations significantly increased collagen synthesis. The maximum effects for both parameters were observed at 10 ng/ml. P. ginseng stimulated human dermal fibroblast proliferation and collagen synthesis at an optimal concentration of 10 ng/ml.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalInternational Wound Journal
Publication statusPublished - 2016 Mar 1
Externally publishedYes


  • Fibroblast
  • Ginseng
  • Panax ginseng
  • Wound healing

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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