Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

Su Hyuk Chi; Hyun Ghang Jeong; Suji Lee; So Young Oh; Seung Hyun Kim

doi:10.4306/pi.2017.14.5.647

Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

Su Hyuk Chi, Hyun Ghang Jeong, Suji Lee, So Young Oh, Seung Hyun Kim

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST_10th), and the mean difference in ST between the first and last sessions (mean ΔST_last). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST_10th (β=0.486, p<0.01) and mean ΔST_last (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

Original language	English
Pages (from-to)	647-655
Number of pages	9
Journal	Psychiatry Investigation
Volume	14
Issue number	5
DOIs	https://doi.org/10.4306/pi.2017.14.5.647
Publication status	Published - 2017 Sept
Externally published	Yes

Keywords

Antidepressants
Antipsychotics
Electroconvulsive therapy
Seizure threshold

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4306/pi.2017.14.5.647

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title = "Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy",

abstract = "Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.",

keywords = "Antidepressants, Antipsychotics, Electroconvulsive therapy, Seizure threshold",

author = "Chi, {Su Hyuk} and Jeong, {Hyun Ghang} and Suji Lee and Oh, {So Young} and Kim, {Seung Hyun}",

note = "Funding Information: This study was supported by a grant from the Korea University, Republic of Korea (K1512631). Publisher Copyright: {\textcopyright} 2017 Korean Neuropsychiatric Association.",

year = "2017",

month = sep,

doi = "10.4306/pi.2017.14.5.647",

language = "English",

volume = "14",

pages = "647--655",

journal = "Psychiatry Investigation",

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TY - JOUR

T1 - Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

AU - Chi, Su Hyuk

AU - Jeong, Hyun Ghang

AU - Lee, Suji

AU - Oh, So Young

AU - Kim, Seung Hyun

PY - 2017/9

Y1 - 2017/9

N2 - Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

AB - Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

KW - Antidepressants

KW - Antipsychotics

KW - Electroconvulsive therapy

KW - Seizure threshold

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DO - 10.4306/pi.2017.14.5.647

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JO - Psychiatry Investigation

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Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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