TY - JOUR
T1 - Effects of rhBMP-2 loaded titanium reinforced collagen membranes on horizontal bone augmentation in dogs
AU - Lee, Ki Sun
AU - Jeon, Yu Sung
AU - Shin, Sang Wan
AU - Lee, Jeong Yol
N1 - Publisher Copyright:
© 2017 Ki-Sun Lee et al.
PY - 2017
Y1 - 2017
N2 - The aim of this study was to evaluate the efficacy of growth factor loaded collagen membranes on new bone formation during horizontal bone augmentation. Mandibular defects (4 × 4 × 4 mm) were surgically prepared in six male beagle dogs, which were then protected with one of three types of membranes: (1) titanium mesh, (2) titanium reinforced collagen, or (3) rhBMP-2 loaded titanium reinforced collagen. Animals were euthanized 8 and 16 weeks after surgery, and nondecalcified specimens were prepared and histomorphologically investigated to determine the degree of osteogenesis.Datawere analyzed with Friedman test. With respect to the degree of osteogenesis at earlier stage (8weeks after surgery), there was significantly higher newbone ratio in rhBMP-2 loaded membrane group (p > 0.05). However, with respect to the long-term results (16 weeks after surgery), there were no significant differences among the three membranes (p > 0.05). Based on histomorphometric analysis, there were no significant differences in horizontal bone gaining ratio (p > 0.05).
AB - The aim of this study was to evaluate the efficacy of growth factor loaded collagen membranes on new bone formation during horizontal bone augmentation. Mandibular defects (4 × 4 × 4 mm) were surgically prepared in six male beagle dogs, which were then protected with one of three types of membranes: (1) titanium mesh, (2) titanium reinforced collagen, or (3) rhBMP-2 loaded titanium reinforced collagen. Animals were euthanized 8 and 16 weeks after surgery, and nondecalcified specimens were prepared and histomorphologically investigated to determine the degree of osteogenesis.Datawere analyzed with Friedman test. With respect to the degree of osteogenesis at earlier stage (8weeks after surgery), there was significantly higher newbone ratio in rhBMP-2 loaded membrane group (p > 0.05). However, with respect to the long-term results (16 weeks after surgery), there were no significant differences among the three membranes (p > 0.05). Based on histomorphometric analysis, there were no significant differences in horizontal bone gaining ratio (p > 0.05).
UR - http://www.scopus.com/inward/record.url?scp=85040983263&partnerID=8YFLogxK
U2 - 10.1155/2017/7141296
DO - 10.1155/2017/7141296
M3 - Article
C2 - 29181402
AN - SCOPUS:85040983263
SN - 2314-6133
VL - 2017
JO - BioMed Research International
JF - BioMed Research International
M1 - 7141296
ER -