Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis

Ji Hyun Jeong, Ha Lim Lee, Hyun Ji Park, Ye Eun Yoon, Jaeeun Shin, Mi Young Jeong, Sung Hoon Park, Da hye Kim, Seung Woo Han, Choon Gil Kang, Ki Ju Hong, Sung Joon Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Tomatoes include high levels of lycopene, which is a potent antioxidative, hypolipidemic, and antidiabetic phytochemical. The intake of lycopene is associated with a reduced risk of insulin resistance and metabolic syndrome. The aim of this study was to investigate whether tomato ketchup and tomato paste, major dietary sources for tomato and lycopene, could regulate hepatic lipid metabolism and adipogenesis. To investigate the regulatory effects of tomato ketchup and tomato paste, we prepared a tomato ketchup extract (TKE) and a tomato paste extract (TPE) in 80% (v/v) ethyl acetate for the experiment. TKE and TPE reduced lipid accumulation and key markers for gluconeogenesis and induced a higher rate of fatty acid oxidation in HepG2 hepatocytes. In 3T3-L1 adipocytes, TKE and TPE increased adipogenesis and intracellular triglyceride accumulation, and stimulated glucose uptake. Peroxisome proliferator-activated receptor alpha and gamma expression levels were increased by TKE and TPE treatment. A single oral dose of tomato ketchup and tomato paste (9.28 g/kg) significantly improved glucose and insulin tolerance in mice. These findings suggest that lycopene-containing tomato ketchup and tomato paste may have beneficial regulatory effects in terms of energy metabolism in hepatocytes and adipocytes, and thus may improve blood glucose metabolism.

Original languageEnglish
Pages (from-to)1111-1122
Number of pages12
JournalFood Science and Biotechnology
Issue number8
Publication statusPublished - 2023 Jul

Bibliographical note

Publisher Copyright:
© 2023, The Korean Society of Food Science and Technology.


  • Adipogenesis
  • Hepatic lipid metabolism
  • Lycopene
  • Tomato ketchup

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


Dive into the research topics of 'Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis'. Together they form a unique fingerprint.

Cite this