Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

Yong Seok Jee; Il Gyu Ko; Yun Hee Sung; Jin Woo Lee; Young Sick Kim; Sung Eun Kim; Bo Kyun Kim; Jin Hee Seo; Mal Soon Shin; Hee Hyuk Lee; Han Jin Cho; Chang Ju Kim

doi:10.1016/j.neulet.2008.07.078

Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

Yong Seok Jee, Il Gyu Ko, Yun Hee Sung, Jin Woo Lee, Young Sick Kim, Sung Eun Kim, Bo Kyun Kim, Jin Hee Seo, Mal Soon Shin, Hee Hyuk Lee, Han Jin Cho, Chang Ju Kim

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48 Citations (Scopus)

Abstract

Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

Original language	English
Pages (from-to)	188-192
Number of pages	5
Journal	Neuroscience Letters
Volume	443
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2008.07.078
Publication status	Published - 2008 Oct 10
Externally published	Yes

Keywords

Alzheimer' disease
Hippocampus
Long-term memory
Streptozotocin
Treadmill exercise
c-Fos

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2008.07.078

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Jee, Y. S., Ko, I. G., Sung, Y. H., Lee, J. W., Kim, Y. S., Kim, S. E., Kim, B. K., Seo, J. H., Shin, M. S., Lee, H. H., Cho, H. J., & Kim, C. J. (2008). Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin. Neuroscience Letters, 443(3), 188-192. https://doi.org/10.1016/j.neulet.2008.07.078

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title = "Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin",

abstract = "Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.",

keywords = "Alzheimer' disease, Hippocampus, Long-term memory, Streptozotocin, Treadmill exercise, c-Fos",

author = "Jee, {Yong Seok} and Ko, {Il Gyu} and Sung, {Yun Hee} and Lee, {Jin Woo} and Kim, {Young Sick} and Kim, {Sung Eun} and Kim, {Bo Kyun} and Seo, {Jin Hee} and Shin, {Mal Soon} and Lee, {Hee Hyuk} and Cho, {Han Jin} and Kim, {Chang Ju}",

note = "Funding Information: This research was supported by the MIC (Ministry of Information and Communication), Korea, under the ITRC (Information Technology Reasearch Center) support program supervised by the IITA (Institute of Information Technology Advancement) (IITA-2006-(C1090-0602-0002)). ",

year = "2008",

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doi = "10.1016/j.neulet.2008.07.078",

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pages = "188--192",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

AU - Jee, Yong Seok

AU - Ko, Il Gyu

AU - Sung, Yun Hee

AU - Lee, Jin Woo

AU - Kim, Young Sick

AU - Kim, Sung Eun

AU - Kim, Bo Kyun

AU - Seo, Jin Hee

AU - Shin, Mal Soon

AU - Lee, Hee Hyuk

AU - Cho, Han Jin

AU - Kim, Chang Ju

N1 - Funding Information: This research was supported by the MIC (Ministry of Information and Communication), Korea, under the ITRC (Information Technology Reasearch Center) support program supervised by the IITA (Institute of Information Technology Advancement) (IITA-2006-(C1090-0602-0002)).

PY - 2008/10/10

Y1 - 2008/10/10

N2 - Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

AB - Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

KW - Alzheimer' disease

KW - Hippocampus

KW - Long-term memory

KW - Streptozotocin

KW - Treadmill exercise

KW - c-Fos

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DO - 10.1016/j.neulet.2008.07.078

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SN - 0304-3940

VL - 443

SP - 188

EP - 192

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

Abstract

Keywords

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