Abstract
Bioavailability and bone loss inhibitory effects of vitamin D2 derived from UV-irradiated shiitake mushroom were determined in vivo. The effect of the absence of ovaries on the bioavailability of vitamin D2 and bone structure was also investigated. Sham operated (sham) and ovariectomized (OVX) rats were divided in 3 groups according to their diets, i.e. control: only vitamin D-deficient diets; UV(X): vitamin D-deficient diets with non-irradiated mushroom powder; UV(O): vitamin D-deficient diets with irradiated mushroom powder. The obtained results showed that vitamin D2 from shiitake mushroom was able to increase bone mineral density and trabecular bone structure of femur bone as well as its bioavailability. The absence of estrogen induced adverse effects not only on bioavailability of vitamin D2 but also on trabecular bone. In conclusion, vitamin D2-fortified shiitake mushroom might help postmenopausal women increase vitamin D2 bioavailability and retard trabecular bone loss.
Original language | English |
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Pages (from-to) | 942-951 |
Number of pages | 10 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 83 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2019 |
Bibliographical note
Funding Information:This work was supported by a grant from the Institute of Biomedical Science & Food Safety and the School of Life Sciences and Biotechnology for BK21PLUS, Korea University and High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (114021021HD020).
Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group
Keywords
- Bioavailability
- Microarchitecture
- Ovariectomized rats
- Shiitake mushroom
- Vitamin D
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry