Effects of Vitamin D2-fortified shiitake mushroom on bioavailability and bone structure

Dong Jae Won; Ki Seung Seong; Cheol Ho Jang; Jin Sil Lee; Jung A. Ko; Hojae Bae; Hyun Jin Park

doi:10.1080/09168451.2019.1576497

Effects of Vitamin D₂-fortified shiitake mushroom on bioavailability and bone structure

Dong Jae Won, Ki Seung Seong, Cheol Ho Jang, Jin Sil Lee, Jung A. Ko, Hojae Bae, Hyun Jin Park

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Bioavailability and bone loss inhibitory effects of vitamin D₂ derived from UV-irradiated shiitake mushroom were determined in vivo. The effect of the absence of ovaries on the bioavailability of vitamin D₂ and bone structure was also investigated. Sham operated (sham) and ovariectomized (OVX) rats were divided in 3 groups according to their diets, i.e. control: only vitamin D-deficient diets; UV(X): vitamin D-deficient diets with non-irradiated mushroom powder; UV(O): vitamin D-deficient diets with irradiated mushroom powder. The obtained results showed that vitamin D₂ from shiitake mushroom was able to increase bone mineral density and trabecular bone structure of femur bone as well as its bioavailability. The absence of estrogen induced adverse effects not only on bioavailability of vitamin D₂ but also on trabecular bone. In conclusion, vitamin D₂-fortified shiitake mushroom might help postmenopausal women increase vitamin D₂ bioavailability and retard trabecular bone loss.

Original language	English
Pages (from-to)	942-951
Number of pages	10
Journal	Bioscience, Biotechnology and Biochemistry
Volume	83
Issue number	5
DOIs	https://doi.org/10.1080/09168451.2019.1576497
Publication status	Published - 2019

Bibliographical note

Funding Information:
This work was supported by a grant from the Institute of Biomedical Science & Food Safety and the School of Life Sciences and Biotechnology for BK21PLUS, Korea University and High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (114021021HD020).

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group

Keywords

Bioavailability
Microarchitecture
Ovariectomized rats
Shiitake mushroom
Vitamin D

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1080/09168451.2019.1576497

Cite this

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title = "Effects of Vitamin D2-fortified shiitake mushroom on bioavailability and bone structure",

abstract = "Bioavailability and bone loss inhibitory effects of vitamin D2 derived from UV-irradiated shiitake mushroom were determined in vivo. The effect of the absence of ovaries on the bioavailability of vitamin D2 and bone structure was also investigated. Sham operated (sham) and ovariectomized (OVX) rats were divided in 3 groups according to their diets, i.e. control: only vitamin D-deficient diets; UV(X): vitamin D-deficient diets with non-irradiated mushroom powder; UV(O): vitamin D-deficient diets with irradiated mushroom powder. The obtained results showed that vitamin D2 from shiitake mushroom was able to increase bone mineral density and trabecular bone structure of femur bone as well as its bioavailability. The absence of estrogen induced adverse effects not only on bioavailability of vitamin D2 but also on trabecular bone. In conclusion, vitamin D2-fortified shiitake mushroom might help postmenopausal women increase vitamin D2 bioavailability and retard trabecular bone loss.",

keywords = "Bioavailability, Microarchitecture, Ovariectomized rats, Shiitake mushroom, Vitamin D",

author = "Won, {Dong Jae} and Seong, {Ki Seung} and Jang, {Cheol Ho} and Lee, {Jin Sil} and Ko, {Jung A.} and Hojae Bae and Park, {Hyun Jin}",

note = "Funding Information: This work was supported by a grant from the Institute of Biomedical Science & Food Safety and the School of Life Sciences and Biotechnology for BK21PLUS, Korea University and High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (114021021HD020). Publisher Copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group",

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AU - Seong, Ki Seung

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AU - Lee, Jin Sil

AU - Ko, Jung A.

AU - Bae, Hojae

AU - Park, Hyun Jin

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PY - 2019

Y1 - 2019

N2 - Bioavailability and bone loss inhibitory effects of vitamin D2 derived from UV-irradiated shiitake mushroom were determined in vivo. The effect of the absence of ovaries on the bioavailability of vitamin D2 and bone structure was also investigated. Sham operated (sham) and ovariectomized (OVX) rats were divided in 3 groups according to their diets, i.e. control: only vitamin D-deficient diets; UV(X): vitamin D-deficient diets with non-irradiated mushroom powder; UV(O): vitamin D-deficient diets with irradiated mushroom powder. The obtained results showed that vitamin D2 from shiitake mushroom was able to increase bone mineral density and trabecular bone structure of femur bone as well as its bioavailability. The absence of estrogen induced adverse effects not only on bioavailability of vitamin D2 but also on trabecular bone. In conclusion, vitamin D2-fortified shiitake mushroom might help postmenopausal women increase vitamin D2 bioavailability and retard trabecular bone loss.

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