Effects of α1- and α2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain

Sun Kwang Kim; Byung Il Min; Ji Hoon Kim; Byung Gil Hwang; Gi Yong Yoo; Dong Suk Park; Heung Sik Na

doi:10.1016/j.brainres.2005.01.051

Effects of α1- and α2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain

Sun Kwang Kim, Byung Il Min, Ji Hoon Kim, Byung Gil Hwang, Gi Yong Yoo, Dong Suk Park, Heung Sik Na

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Systemic administrations (0.1, 0.5, and 2 mg/kg) of α1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas α2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of α1- and α2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by α1-AR antagonist and exacerbated by α2-AR antagonist.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Brain Research
Volume	1039
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.01.051
Publication status	Published - 2005 Mar 28

Bibliographical note

Funding Information:
This work was supported by a grant from Ministry of Health and Welfare, Republic of Korea (HMP-00-CO-01-0001).

Keywords

Cold allodynia
Neuropathic pain
Prazosin
Yohimbine
α1-adrenoreceptor
α2-adrenoreceptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2005.01.051

Cite this

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title = "Effects of α1- and α2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain",

abstract = "Systemic administrations (0.1, 0.5, and 2 mg/kg) of α1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas α2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of α1- and α2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by α1-AR antagonist and exacerbated by α2-AR antagonist.",

keywords = "Cold allodynia, Neuropathic pain, Prazosin, Yohimbine, α1-adrenoreceptor, α2-adrenoreceptor",

author = "Kim, {Sun Kwang} and Min, {Byung Il} and Kim, {Ji Hoon} and Hwang, {Byung Gil} and Yoo, {Gi Yong} and Park, {Dong Suk} and Na, {Heung Sik}",

note = "Funding Information: This work was supported by a grant from Ministry of Health and Welfare, Republic of Korea (HMP-00-CO-01-0001).",

year = "2005",

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doi = "10.1016/j.brainres.2005.01.051",

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AU - Kim, Sun Kwang

AU - Min, Byung Il

AU - Kim, Ji Hoon

AU - Hwang, Byung Gil

AU - Yoo, Gi Yong

AU - Park, Dong Suk

AU - Na, Heung Sik

N1 - Funding Information: This work was supported by a grant from Ministry of Health and Welfare, Republic of Korea (HMP-00-CO-01-0001).

PY - 2005/3/28

Y1 - 2005/3/28

N2 - Systemic administrations (0.1, 0.5, and 2 mg/kg) of α1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas α2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of α1- and α2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by α1-AR antagonist and exacerbated by α2-AR antagonist.

AB - Systemic administrations (0.1, 0.5, and 2 mg/kg) of α1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas α2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of α1- and α2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by α1-AR antagonist and exacerbated by α2-AR antagonist.

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KW - Neuropathic pain

KW - Prazosin

KW - Yohimbine

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KW - α2-adrenoreceptor

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Effects of α1- and α2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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