Efficacy and safety of dual-drug-eluting stents for de novo coronary lesions in south korea—the effect trial

Jung Joon Cha, Gi Chang Kim, Seung Ho Hur, Jang Ho Bae, Jae Woong Choi, Dong Kyu Jin, Seong Il Woo, Seung Uk Lee, Jong Seon Park, Yun Hyeong Cho, Cheol Ung Choi, Do Sun Lim, Tae Hoon Ahn

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; however, complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. This study investigated the safety and efficacy of dual-DES in clinical practice. Methods: This study included 375 patients who underwent PCI with Cilotax or DXR dual-DESs at one of 13 centers in South Korea. The primary endpoint was target lesion failure (TLF) within 1 year. The secondary endpoints were cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Results: The rates of TLF in dual-DESs (3.7%) were comparable to those reported in conventional DES. In addition, the DXR group had a significantly lower rate of TLF than the Cilotax group. In multivariate analysis, the DXR group had a lower risk of TLF (adjusted hazard ratio (HR) 0.30, 95% CI 0.09–0.92, p = 0.036) and MI (adjusted HR 0.16, 95% CI 0.03–0.82, p = 0.027) than the Cilotax group. Conclusion: Dual-DESs had similar clinical outcomes regarding efficacy and safety as conventional DES. Among the dual-DES, the DXR stent as a new generation dual-DES had more favorable clinical outcomes than the Cilotax stent.

Original languageEnglish
Article number69
Pages (from-to)1-9
Number of pages9
JournalJournal of Clinical Medicine
Issue number1
Publication statusPublished - 2021 Jan
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Li-censee MDPI, Basel, Switzerland.


  • Cilotax stent
  • Clinical outcome
  • Coronary artery disease
  • DXR stent
  • Dual drug-eluting stent

ASJC Scopus subject areas

  • General Medicine


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