Efficacy of drug-eluting stents for treating in-stent restenosis of drug-eluting stents (from the Korean des ISR multicenter registry study [KISS])

Young Guk Ko, Jung Sun Kim, Byeong Keuk Kim, Donghoon Choi, Myeong Ki Hong, Dong Woon Jeon, Joo Young Yang, Young Keun Ahn, Myung Ho Jeong, Cheol Woong Yu, Kyeong Ho Yun, Do Sun Lim, Yangsoo Jang

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18 Citations (Scopus)


There is currently no established standard treatment for in-stent restenosis (ISR) after the implantation of a drug-eluting stent (DES). The aim of this study was to investigate the efficacy of DES versus balloon angioplasty (BA) for the treatment of DES ISR in a multicenter registry cohort. After matching propensity scores of 805 patients with DES ISR treated with either DES (n = 422) or BA (n = 383), 268 matched pairs were selected and analyzed for major adverse cardiac events, a composite of death, myocardial infarction, and target-vessel revascularization, as the primary end point. Baseline clinical and lesion characteristics of the matched pairs were similar. Survival free of major adverse cardiac events at 2 years was higher with DES compared to BA (88.9% vs 78.7%, p <0.001), mainly because of higher TVR-free survival (92.4% vs 81.0%, p <0.001). Among various baseline variables, BA (hazard ratio 2.546, 95% confidence interval 1.412 to 4.593, p = 0.002) was the most important independent risk factor for recurrent target vessel revascularization, followed by acute coronary syndromes as the clinical presentation of DES ISR, and previous implantation of a sirolimus-eluting stent. Survival free of death, myocardial infarction, or stent thrombosis did not differ between the 2 groups. Whereas there was no significant difference in survival free of target vessel revascularization between DES and BA for focal ISR lesions, DES was superior to BA in diffuse ISR lesions (94.3% vs 75.2% at 2 years, p <0.001). In conclusion, compared to BA, the implantation of DES was safe and more effective in the treatment of DES ISR.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalAmerican Journal of Cardiology
Issue number5
Publication statusPublished - 2012 Mar 1
Externally publishedYes

Bibliographical note

Funding Information:
This study was partly supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs , Republic of Korea (Grants A085012 and A102064 ); a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare , Republic of Korea (Grant A085136 ), and the Cardiovascular Research Center, Seoul, Korea.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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