Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Hee Joon Lee; Kyungho Park; Goun Bae; Jaehoon Choe; Kwang Ho Song; Sunwoo Lee

doi:10.1016/j.tetlet.2011.07.091

Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Hee Joon Lee, Kyungho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo Lee

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.

Original language	English
Pages (from-to)	5064-5067
Number of pages	4
Journal	Tetrahedron Letters
Volume	52
Issue number	39
DOIs	https://doi.org/10.1016/j.tetlet.2011.07.091
Publication status	Published - 2011 Sept 28

Keywords

Decarboxylative coupling
Diaryl alkynes
Flow chemistry
Micromixer
Palladium

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.07.091

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abstract = "Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.",

keywords = "Decarboxylative coupling, Diaryl alkynes, Flow chemistry, Micromixer, Palladium",

author = "Lee, {Hee Joon} and Kyungho Park and Goun Bae and Jaehoon Choe and Song, {Kwang Ho} and Sunwoo Lee",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2008-314-D00070). ",

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AU - Lee, Hee Joon

AU - Park, Kyungho

AU - Bae, Goun

AU - Choe, Jaehoon

AU - Song, Kwang Ho

AU - Lee, Sunwoo

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2008-314-D00070).

PY - 2011/9/28

Y1 - 2011/9/28

N2 - Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.

AB - Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.

KW - Decarboxylative coupling

KW - Diaryl alkynes

KW - Flow chemistry

KW - Micromixer

KW - Palladium

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DO - 10.1016/j.tetlet.2011.07.091

M3 - Article

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SP - 5064

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Abstract

Keywords

ASJC Scopus subject areas

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