Eicosapentaenoic Acid (EPA) modulates glucose metabolism by targeting AMP-Activated Protein Kinase (AMPK) pathway

Nami Kim, Mi Sun Kang, Miso Nam, Shin Ae Kim, Geum Sook Hwang, Hyeon Soo Kim

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


EPA, an omega-3 polyunsaturated fatty acid, exerts beneficial effects on human health. However, the molecular mechanisms underlying EPA function are poorly understood. The object was to illuminate molecular mechanism underlying EPA’s role. Here, 1H-NMR-based metabolic analysis showed enhanced branched-chain amino acids (BCAAs) and lactate following EPA treatment in skeletal muscle cells. EPA regulated mitochondrial oxygen consumption rate. Furthermore, EPA induced calcium/calmodulin-dependent protein kinase kinase (CaMKK) through the generation of intracellular calcium. This induced the phosphorylation of AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) that led to glucose uptake, and the translocation of glucose transporter type 4 (GLUT4) in muscles. In conclusion, EPA exerts benign effects on glucose through the activation of AMPK-p38 MAPK signaling pathways in skeletal muscles.

Original languageEnglish
Article number4751
JournalInternational journal of molecular sciences
Issue number19
Publication statusPublished - 2019 Oct 1


  • AMPK
  • EPA
  • GLUT4
  • Oxygen consumption

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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