Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression

Sungmin Han; Dong Hwee Kim; Joohwan Sung; Hwasun Yang; Jong Woong Park; Inchan Youn

doi:10.1016/j.bbrc.2018.11.159

Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression

Sungmin Han
, Dong Hwee Kim
, Joohwan Sung
, Hwasun Yang
, Jong Woong Park
, Inchan Youn^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites.

Original language	English
Pages (from-to)	348-353
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	508
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2018.11.159
Publication status	Published - 2019 Jan 8

Bibliographical note

Funding Information:
This research was supported in part by a grant the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C3477) and the National Research Council of Science & Technology grant by the Korea government (MSIT) (No. CAP-18-01-KIST).

Funding Information:
This research was supported in part by a grant the Korea Health Technology R&D Project through the Korea Health Industry Development Institute , funded by the Ministry of Health and Welfare, Republic of Korea ( HI14C3477 ) and the National Research Council of Science & Technology grant by the Korea government (MSIT) (No. CAP-18-01-KIST ).

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Dorsal root ganglion
Electrical stimulation
Matrix metalloproteinase
Neurite regeneration

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2018.11.159

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title = "Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression",

abstract = "Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites.",

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AU - Youn, Inchan

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N2 - Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites.

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Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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