Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes

Yang Rae Kim; Sungyool Bong; Yeon Joo Kang; Yongtak Yang; Rakesh Kumar Mahajan; Jong Seung Kim; Hasuck Kim

doi:10.1016/j.bios.2010.02.031

Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes

Yang Rae Kim, Sungyool Bong, Yeon Joo Kang, Yongtak Yang, Rakesh Kumar Mahajan, Jong Seung Kim, Hasuck Kim

Research output: Contribution to journal › Article › peer-review

653 Citations (Scopus)

Abstract

Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1. mM). The observed linear range for the determination of dopamine concentration was from 4μM to 100μM. The detection limit was estimated to be 2.64μM.

Original language	English
Pages (from-to)	2366-2369
Number of pages	4
Journal	Biosensors and Bioelectronics
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.bios.2010.02.031
Publication status	Published - 2010 Jun

Keywords

Ascorbic acid
Cyclic voltammetry
Dopamine
Electrochemical impedance spectroscopy
Graphene

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2010.02.031

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title = "Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes",

abstract = "Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1. mM). The observed linear range for the determination of dopamine concentration was from 4μM to 100μM. The detection limit was estimated to be 2.64μM.",

keywords = "Ascorbic acid, Cyclic voltammetry, Dopamine, Electrochemical impedance spectroscopy, Graphene",

author = "Kim, {Yang Rae} and Sungyool Bong and Kang, {Yeon Joo} and Yongtak Yang and Mahajan, {Rakesh Kumar} and Kim, {Jong Seung} and Hasuck Kim",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MEST) (No. R11-2005-008-06002-0 ) and CRI project ( 2009-0081566 ). Y.-R. Kim, S. Bong, Y.-J. Kang, and Y.T. Yang were supported by the Brain Korea 21 fellowship. R.K. Mahajan was supported by the Korean Federation of Science and Technology Societies (KOFST) ( 082S-1-3-0195 ). ",

year = "2010",

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doi = "10.1016/j.bios.2010.02.031",

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AU - Mahajan, Rakesh Kumar

AU - Kim, Jong Seung

AU - Kim, Hasuck

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MEST) (No. R11-2005-008-06002-0 ) and CRI project ( 2009-0081566 ). Y.-R. Kim, S. Bong, Y.-J. Kang, and Y.T. Yang were supported by the Brain Korea 21 fellowship. R.K. Mahajan was supported by the Korean Federation of Science and Technology Societies (KOFST) ( 082S-1-3-0195 ).

PY - 2010/6

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N2 - Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1. mM). The observed linear range for the determination of dopamine concentration was from 4μM to 100μM. The detection limit was estimated to be 2.64μM.

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Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes

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Keywords

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