Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells such as muscles and vertebral bones, and neural lineage cells such as neural crests and central nervous system neurons. Such diverse lineage potential combined with a limited capacity for self-renewal, which persists during axial elongation, demonstrates that NMPs are a major source of trunk tissues. This review describes the identification and characterization of NMPs across multiple species. We also discuss key cellular and molecular steps for generating neural and mesodermal cells for building up the elongating trunk tissue.
Bibliographical noteFunding Information:
MRS is supported by the MRFF Leukodystrophy Flagship – Massimo’s Mission (EPCD000034). JHL and WS are supported by the Brain Research Program through the National Research Foundation (NRF), which was funded by the Korean Ministry of Science, ICT & Future Planning (NRF-2015M3C7A1028790, NRF-2017M3A9B3061308, and NRF-2017M3C7A1047654).
© 2021 The Korean Neurosurgical Society.
- Axial elongation
- Neural tube
- Neuromesodermal progenitors
- Spinal cord development
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology