Emerging 2D material-based nanocarrier for cancer therapy beyond graphene

Yingwei Wang; Meng Qiu; Miae Won; Eugeine Jung; Taojian Fan; Ni Xie; Sung Gil Chi; Han Zhang; Jong Seung Kim

doi:10.1016/j.ccr.2019.213041

Emerging 2D material-based nanocarrier for cancer therapy beyond graphene

Yingwei Wang, Meng Qiu, Miae Won, Eugeine Jung, Taojian Fan, Ni Xie, Sung Gil Chi, Han Zhang, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

119 Citations (Scopus)

Abstract

2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.

Original language	English
Article number	213041
Journal	Coordination Chemistry Reviews
Volume	400
DOIs	https://doi.org/10.1016/j.ccr.2019.213041
Publication status	Published - 2019 Dec 1

Bibliographical note

Funding Information:
This research was supported in partially by the National Natural Science Fund, China (Grant No. 61875138, 61435010, 11904239 and 6181101252), and Science and Technology Innovation Commission of Shenzhen, China (KQTD2015032416270385, JCYJ20150625103619275, JCYJ20170818141407343, JCYJ20170818141519879, JCYJ20170818141429525 and JCYJ20170811093453105). China Postdoctoral Science Foundation, China (Grants 2017M620383; 2018M633118; 2018M633127). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702, J.S.K.) and a NRF, South Korea grant (Grant No. 2018R1A2A1A05020236, S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062, M.W.) from the National Research Foundation of Korea, South Korea.

Funding Information:
This research was supported in partially by the National Natural Science Fund , China (Grant No. 61875138 , 61435010 , 11904239 and 6181101252 ), and Science and Technology Innovation Commission of Shenzhen , China ( KQTD2015032416270385 , JCYJ20150625103619275 , JCYJ20170818141407343 , JCYJ20170818141519879 , JCYJ20170818141429525 and JCYJ20170811093453105 ). China Postdoctoral Science Foundation , China (Grants 2017M620383 ; 2018M633118 ; 2018M633127 ). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702 , J.S.K.) and a NRF , South Korea grant (Grant No. 2018R1A2A1A05020236 , S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062 , M.W.) from the National Research Foundation of Korea , South Korea.

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

2D material
Cancer therapy
Drug delivery
Nanocarrier
Nanomaterial

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2019.213041

Cite this

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title = "Emerging 2D material-based nanocarrier for cancer therapy beyond graphene",

abstract = "2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.",

keywords = "2D material, Cancer therapy, Drug delivery, Nanocarrier, Nanomaterial",

author = "Yingwei Wang and Meng Qiu and Miae Won and Eugeine Jung and Taojian Fan and Ni Xie and Chi, {Sung Gil} and Han Zhang and Kim, {Jong Seung}",

note = "Funding Information: This research was supported in partially by the National Natural Science Fund, China (Grant No. 61875138, 61435010, 11904239 and 6181101252), and Science and Technology Innovation Commission of Shenzhen, China (KQTD2015032416270385, JCYJ20150625103619275, JCYJ20170818141407343, JCYJ20170818141519879, JCYJ20170818141429525 and JCYJ20170811093453105). China Postdoctoral Science Foundation, China (Grants 2017M620383; 2018M633118; 2018M633127). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702, J.S.K.) and a NRF, South Korea grant (Grant No. 2018R1A2A1A05020236, S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062, M.W.) from the National Research Foundation of Korea, South Korea. Funding Information: This research was supported in partially by the National Natural Science Fund , China (Grant No. 61875138 , 61435010 , 11904239 and 6181101252 ), and Science and Technology Innovation Commission of Shenzhen , China ( KQTD2015032416270385 , JCYJ20150625103619275 , JCYJ20170818141407343 , JCYJ20170818141519879 , JCYJ20170818141429525 and JCYJ20170811093453105 ). China Postdoctoral Science Foundation , China (Grants 2017M620383 ; 2018M633118 ; 2018M633127 ). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702 , J.S.K.) and a NRF , South Korea grant (Grant No. 2018R1A2A1A05020236 , S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062 , M.W.) from the National Research Foundation of Korea , South Korea. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

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doi = "10.1016/j.ccr.2019.213041",

language = "English",

volume = "400",

journal = "Coordination Chemistry Reviews",

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AU - Wang, Yingwei

AU - Qiu, Meng

AU - Won, Miae

AU - Jung, Eugeine

AU - Fan, Taojian

AU - Xie, Ni

AU - Chi, Sung Gil

AU - Zhang, Han

AU - Kim, Jong Seung

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N2 - 2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.

AB - 2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.

KW - 2D material

KW - Cancer therapy

KW - Drug delivery

KW - Nanocarrier

KW - Nanomaterial

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DO - 10.1016/j.ccr.2019.213041

M3 - Review article

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SN - 0010-8545

VL - 400

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

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Emerging 2D material-based nanocarrier for cancer therapy beyond graphene

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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