Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie; Taojian Fan; Jusung An; Wonseok Choi; Yanhong Duo; Yanqi Ge; Bin Zhang; Guohui Nie; Ni Xie; Tingting Zheng; Yun Chen; Han Zhang; Jong Seung Kim

doi:10.1039/d0cs00215a

Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie, Taojian Fan, Jusung An, Wonseok Choi, Yanhong Duo, Yanqi Ge, Bin Zhang, Guohui Nie, Ni Xie, Tingting Zheng, Yun Chen, Han Zhang, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

570 Citations (Scopus)

Abstract

Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics"becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.

Original language	English
Pages (from-to)	8065-8087
Number of pages	23
Journal	Chemical Society Reviews
Volume	49
Issue number	22
DOIs	https://doi.org/10.1039/d0cs00215a
Publication status	Published - 2020 Nov 21

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Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

General Chemistry

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title = "Emerging combination strategies with phototherapy in cancer nanomedicine",

abstract = "Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with {"}biomedical optics{"}becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.",

author = "Zhongjian Xie and Taojian Fan and Jusung An and Wonseok Choi and Yanhong Duo and Yanqi Ge and Bin Zhang and Guohui Nie and Ni Xie and Tingting Zheng and Yun Chen and Han Zhang and Kim, {Jong Seung}",

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doi = "10.1039/d0cs00215a",

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T1 - Emerging combination strategies with phototherapy in cancer nanomedicine

AU - Xie, Zhongjian

AU - Fan, Taojian

AU - An, Jusung

AU - Choi, Wonseok

AU - Duo, Yanhong

AU - Ge, Yanqi

AU - Zhang, Bin

AU - Nie, Guohui

AU - Xie, Ni

AU - Zheng, Tingting

AU - Chen, Yun

AU - Zhang, Han

AU - Kim, Jong Seung

PY - 2020/11/21

Y1 - 2020/11/21

N2 - Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics"becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.

AB - Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics"becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.

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JO - Chemical Society Reviews

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ER -

Emerging combination strategies with phototherapy in cancer nanomedicine

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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