Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie, Taojian Fan, Jusung An, Wonseok Choi, Yanhong Duo, Yanqi Ge, Bin Zhang, Guohui Nie, Ni Xie, Tingting Zheng, Yun Chen, Han Zhang, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

455 Citations (Scopus)


Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics"becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.

Original languageEnglish
Pages (from-to)8065-8087
Number of pages23
JournalChemical Society Reviews
Issue number22
Publication statusPublished - 2020 Nov 21

Bibliographical note

Funding Information:
This work was supported by the State Key Research Development Program of China (Grant No. 2019YFB2203503), the National Natural Science Fund (Grant No. 61875138, 61435010, 81871358, U1801254 and 61961136001), and the Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20180307164612205, and GJHZ20180928160209731). This work was also supported by a CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea. The Natural Science Foundation of Guangdong Province (Grant No. 2020A151501612) is grateful acknowledged. Guangdong Basic and Applied Basic Research Foundation (2019B1515120043), the Science and Technology Project of Shenzhen (JCYJ20180508152903208), Longhua District Science and Innovation Commission Project Grants of Shenzhen (JCYJ201904) are grateful acknowledged. The authors also acknowledge the support from the Instrumental Analysis Center of Shenzhen University (Xili Campus).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry


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