Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy

Gi Hoon Nam, Yoonjeong Choi, Gi Beom Kim, Seohyun Kim, Seong A. Kim, In San Kim

Research output: Contribution to journalReview articlepeer-review

179 Citations (Scopus)

Abstract

Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are secreted by most cells and contain various bioactive molecules reflecting their cellular origin and mediate intercellular communication. Studies of these exosomal features in tumor pathogenesis have led to the development of therapeutic and diagnostic approaches using exosomes for cancer therapy. Exosomes have many advantages for conveying therapeutic agents such as small interfering RNAs, microRNAs, membrane-associated proteins, and chemotherapeutic compounds; thus, they are considered a prime candidate as a delivery tool for cancer treatment. Since exosomes also provide an optimal microenvironment for the effective function of immunomodulatory factors, exosomes harboring bioactive molecules have been bioengineered as cancer immunotherapies that can effectively activate each stage of the cancer immunity cycle to successfully elicit cancer-specific immunity. This review discusses the advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development.

Original languageEnglish
Article number2002440
JournalAdvanced Materials
Volume32
Issue number51
DOIs
Publication statusPublished - 2020 Dec 22

Bibliographical note

Funding Information:
G.-H.N. and Y.C. contributed equally to this work. This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT, 2017R1A3B1023418), by the KU-KIST School Project, and by the KIST Institutional Program. The authors would like to thank Wiley Editing Services for English language editing.

Funding Information:
G.‐H.N. and Y.C. contributed equally to this work. This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT, 2017R1A3B1023418), by the KU‐KIST School Project, and by the KIST Institutional Program. The authors would like to thank Wiley Editing Services for English language editing.

Publisher Copyright:
© 2020 The Authors. Published by Wiley-VCH GmbH

Keywords

  • cancer therapeutics
  • characterization and clinical-grade exosomes
  • exosomes
  • extracellular vesicles
  • immunotherapy

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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