Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata

Nguyen Tuan Hiep, Jaeyoung Kwon, Sungeun Hong, Nahyun Kim, Yuanqiang Guo, Bang Yeon Hwang, Woongchon Mar, Dongho Lee

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Seven pairs of enantiomeric isoflavones (1a/1b–7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC 50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC 50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.

Original languageEnglish
Article number1757
JournalScientific reports
Issue number1
Publication statusPublished - 2019 Dec 1

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© 2019, The Author(s).

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