TY - JOUR
T1 - Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata
AU - Hiep, Nguyen Tuan
AU - Kwon, Jaeyoung
AU - Hong, Sungeun
AU - Kim, Nahyun
AU - Guo, Yuanqiang
AU - Hwang, Bang Yeon
AU - Mar, Woongchon
AU - Lee, Dongho
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Seven pairs of enantiomeric isoflavones (1a/1b–7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC 50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC 50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.
AB - Seven pairs of enantiomeric isoflavones (1a/1b–7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC 50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC 50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85061238977&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-36095-8
DO - 10.1038/s41598-018-36095-8
M3 - Article
C2 - 30741971
AN - SCOPUS:85061238977
SN - 2045-2322
VL - 9
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 1757
ER -