Enantioselective syntheses of decursinol angelate and decursin

Jongdoo Lim, Ik Hwan Kim, Hyeon Ho Kim, Kyung Seop Ahn, Hogyu Han

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The practical enantioselective syntheses of decursinol angelate and decursin were achieved in eight steps from resorcinol. The stereochemistry was addressed using the catalytic asymmetric epoxidation of 7-acetoxy-2,2-dimethylchromene by chiral (salen)Mn complexes as the key step.

Original languageEnglish
Pages (from-to)4001-4003
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number24
DOIs
Publication statusPublished - 2001 Jun 11

Bibliographical note

Funding Information:
This work was supported by the Highly Advanced Program (G7) from the Ministry of Science and Technology, Korea (Grant No. 00-G-NB-01-C-008). Fellowship support from the BK21 Program (J.L.) is gratefully acknowledged. The authors would like to thank Professor Nakcheol Jeong for his insightful comments about this work.

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

Keywords

  • Catalytic asymmetric epoxidation
  • Decursin
  • Decursinol
  • Decursinol angelate
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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