Encoding information into autonomously bursting neural network with pairs of time-delayed pulses

June Hoan Kim, Ho Jun Lee, Wonshik Choi, Kyoung J. Lee

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Biological neural networks with many plastic synaptic connections can store external input information in the map of synaptic weights as a form of unsupervised learning. However, the same neural network often produces dramatic reverberating events in which many neurons fire almost simultaneously – a phenomenon coined as ‘population burst.’ The autonomous bursting activity is a consequence of the delicate balance between recurrent excitation and self-inhibition; as such, any periodic sequences of burst-generating stimuli delivered even at a low frequency (~1 Hz) can easily suppress the entire network connectivity. Here we demonstrate that ‘Δt paired-pulse stimulation’, can be a novel way for encoding spatially-distributed high-frequency (~10 Hz) information into such a system without causing a complete suppression. The encoded memory can be probed simply by delivering multiple probing pulses and then estimating the precision of the arrival times of the subsequent evoked recurrent bursts.

Original languageEnglish
Article number1394
JournalScientific reports
Issue number1
Publication statusPublished - 2019 Dec 1

Bibliographical note

Funding Information:
This work was financially supported by the Ministry of Science, ICT & Future Planning (MSIP), of Korea (grant No. NRF-2016R1D1A1B03930591). HJL and WC were also supported by Institute for Basic Science (IBS-R023-D1).

Publisher Copyright:
© 2019, The Author(s).

ASJC Scopus subject areas

  • General


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