Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

Ok Hyun Park, Hongseok Ha, Yujin Lee, Sung Ho Boo, Do Hoon Kwon, Hyun Kyu Song, Yoon Ki Kim

Research output: Contribution to journalArticlepeer-review

353 Citations (Scopus)

Abstract

m6A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m6A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.

Original languageEnglish
Pages (from-to)494-507.e8
JournalMolecular Cell
Volume74
Issue number3
DOIs
Publication statusPublished - 2019 May 2

Bibliographical note

Funding Information:
We thank Dr. Ligang Wu for providing m 6 A reporter plasmids, Dr. Dong-Hoon Jeong for helpful advice on PARE-seq, and Dr. Daehyun Baek for scientific comments on statistical analysis. This work was supported by a National Research Foundation (NRF) of Korea grant funded by the Korean government (Ministry of Science, ICT and Future Planning; NRF-2015R1A3A2033665 and NRF-2018R1A5A1024261 ) and by a Korea University grant, South Korea. O.H.P. and Y.L. were in part supported by the Global Ph.D. Fellowship Program through the NRF funded by the Korean Government, South Korea. H.H. was in part supported by the Basic Science Research Program, through the NRF, funded by the Ministry of Education, South Korea ( NRF-2016R1A6A3A11933750 ).

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • CCR4-NOT complex
  • FTO
  • HRSP12
  • METTL3
  • RNA decay
  • RNase P/MRP
  • YTHDF2
  • circular RNA
  • endoribonucleolytic cleavage
  • mA modification

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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