Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

Ok Hyun Park; Hongseok Ha; Yujin Lee; Sung Ho Boo; Do Hoon Kwon; Hyun Kyu Song; Yoon Ki Kim

doi:10.1016/j.molcel.2019.02.034

Endoribonucleolytic Cleavage of m⁶A-Containing RNAs by RNase P/MRP Complex

Ok Hyun Park
, Hongseok Ha
, Yujin Lee
, Sung Ho Boo
, Do Hoon Kwon
, Hyun Kyu Song
, Yoon Ki Kim^*

^*Corresponding author for this work

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

485 Citations (Scopus)

Abstract

m⁶A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m⁶A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.

Original language	English
Pages (from-to)	494-507.e8
Journal	Molecular Cell
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2019.02.034
Publication status	Published - 2019 May 2

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

CCR4-NOT complex
FTO
HRSP12
METTL3
RNA decay
RNase P/MRP
YTHDF2
circular RNA
endoribonucleolytic cleavage
mA modification

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2019.02.034

Cite this

@article{9da43a18ed4d4888b7996a7679d80a7e,

title = "Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex",

abstract = "m6A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m6A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.",

keywords = "CCR4-NOT complex, FTO, HRSP12, METTL3, RNA decay, RNase P/MRP, YTHDF2, circular RNA, endoribonucleolytic cleavage, mA modification",

author = "Park, \{Ok Hyun\} and Hongseok Ha and Yujin Lee and Boo, \{Sung Ho\} and Kwon, \{Do Hoon\} and Song, \{Hyun Kyu\} and Kim, \{Yoon Ki\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = may,

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doi = "10.1016/j.molcel.2019.02.034",

language = "English",

volume = "74",

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journal = "Molecular Cell",

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T1 - Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

AU - Park, Ok Hyun

AU - Ha, Hongseok

AU - Lee, Yujin

AU - Boo, Sung Ho

AU - Kwon, Do Hoon

AU - Song, Hyun Kyu

AU - Kim, Yoon Ki

PY - 2019/5/2

Y1 - 2019/5/2

N2 - m6A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m6A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.

AB - m6A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m6A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.

KW - CCR4-NOT complex

KW - FTO

KW - HRSP12

KW - METTL3

KW - RNA decay

KW - RNase P/MRP

KW - YTHDF2

KW - circular RNA

KW - endoribonucleolytic cleavage

KW - mA modification

UR - https://www.scopus.com/pages/publications/85064865187

U2 - 10.1016/j.molcel.2019.02.034

DO - 10.1016/j.molcel.2019.02.034

M3 - Article

C2 - 30930054

AN - SCOPUS:85064865187

SN - 1097-2765

VL - 74

SP - 494-507.e8

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -