A single-arm interferometer-based optical coherence tomography (OCT) system known as common-path OCT (CP-OCT) is rapidly progressing towards practical application. Due in part to the simplicity and robustness of its design, Fourier domain CP-OCT (FD-CP-OCT) offers advantages in many endoscopic sensing and imaging applications. FD-CP-OCT uses simple, interchangeable fiber optic probes that are easily integrated into small and delicate surgical tools. The system is capable of providing not only high-resolution imaging but also optical sensing. Here, we report progress towards practical application of FD-CP-OCT in the setting of delicate microsurgical procedures such as intraocular retinal surgery. To meet the challenges presented by the microsurgical requirements of these procedures, we have developed and initiated the validation of applicable fiber optic probes. By integrating these probes into our developing imaging system, we have obtained high-resolution OCT images and have also completed a demonstration of their potential sensing capabilities. Specifically, we utilize multiple superluminescent diodes to demonstrate sub-3-μm axial resolution in water; we propose a technique to quantitatively evaluate the spatial distribution of oxygen saturation levels in tissue; and we present evidence supportive of the technology's surface sensing and tool guidance potential by demonstrating topological and motion compensation capabilities.
|Number of pages||12|
|Journal||IEEE Journal on Selected Topics in Quantum Electronics|
|Publication status||Published - 2010 Jul|
Bibliographical noteFunding Information:
Manuscript received July 30, 2009; revised August 26, 2009; accepted August 26, 2009. Date of publication October 23, 2009; date of current version August 6, 2010. This work was supported in part by the National Institutes of Health under Grant BRP 1R01 EB 007969-01 and Grant R21 1R21NS063131-01A1, and by the National Science Foundation under Grant NSF101485.
- Biomedical optical imaging
- optical fibers
- optical interferometry
- optical tomography
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering