Engineering biomaterials to guide heart cells for matured cardiac tissue

Yongjun Jang, Yongdoo Park, Jongseong Kim

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


The extracellular matrix (ECM) is needed to maintain the structural integrity of tissues and to mediate cellular dynamics. Its main components are fibrous proteins and glycosaminoglycans, which provide a suitable environment for biological functions. Thus, biomaterials with ECM-like properties have been extensively developed by modulating their key components and properties. In the field of cardiac tissue engineering, the use of biomaterials offers several advantages in that biophysical and biochemical cues can be designed to mediate cardiac cells, which is critical for maturation and regeneration. This suggests that understanding biomaterials and their use in vivo and in vitro is beneficial in terms of advancing cardiac engineering. The current review provides an overview of both natural and synthetic biomaterials and their use in cardiac engineering. In addition, we focus on different strategies to recapitulate the cardiac tissue in 2D and 3D approaches, which is an important step for the maturation of cardiac tissues toward regeneration of the adult heart.

Original languageEnglish
Article number925
Pages (from-to)1-24
Number of pages24
Issue number10
Publication statusPublished - 2020 Oct

Bibliographical note

Funding Information:
This research was funded by the National Research Foundation of Korea, Republic of Korea, grant No. 2016-M3A9B6947892 and a Korea University Grant.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • 2D pattern
  • 3D printing
  • Biomaterials
  • Cardiac scaffolds
  • Cardiac spheroids
  • Cardiac tissue engineering
  • Cardiomyocytes
  • Extracellular matrix (ECM)
  • Maturation
  • Surface coating
  • Tissue regeneration

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry


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