Engineering insect flight metabolics using immature stage implanted microfluidics

Aram J. Chung, David Erickson

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Small-scale insect inspired aircraft represent a promising approach to downscaling traditional aircraft designs. Despite advancements in microfabrication, however, it has proven difficult to fully replicate the mechanical complexities that enable these natural systems. As an alternative, recent efforts have used implanted electrical, optical or acoustic microsystems to exert direct control over insect flight. Here we demonstrate, for the first time, a method of directly and reversibly engineering insect flight metabolics using immature stage implanted microfluidics. We present our technique and device for on-command modulation of the internal levels of l-glutamic and l-aspartate acids and quantify the resulting changes in metabolic activity by monitoring respiratory CO2 output. Microfluidic devices implanted 1 to 2 days prior to insects' emergence achieved survivability and flight-capable rates of 96% and 36%, respectively. Behavior ranging from retarded motion to complete, reversible paralysis, over timescales ranging from minutes to hours is demonstrated.

Original languageEnglish
Pages (from-to)669-676
Number of pages8
JournalLab on a Chip
Issue number5
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Biomedical Engineering


Dive into the research topics of 'Engineering insect flight metabolics using immature stage implanted microfluidics'. Together they form a unique fingerprint.

Cite this