Engulfment signals and the phagocytic machinery for apoptotic cell clearance

Seung Yoon Park, In San Kim

Research output: Contribution to journalReview articlepeer-review

97 Citations (Scopus)


The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment.

Original languageEnglish
Article numbere331
JournalExperimental and Molecular Medicine
Issue number5
Publication statusPublished - 2017 May 12

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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