Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells

Ding Ding Guo; Hyun Seuk Moon; Rohidas Arote; Ji Hye Seo; Ji Shan Quan; Yun Jaie Choi; Chong Su Cho

doi:10.1016/j.canlet.2007.03.007

Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells

Ding Ding Guo, Hyun Seuk Moon, Rohidas Arote, Ji Hye Seo, Ji Shan Quan, Yun Jaie Choi, Chong Su Cho

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.

Original language	English
Pages (from-to)	244-254
Number of pages	11
Journal	Cancer letters
Volume	254
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.03.007
Publication status	Published - 2007 Sept 8

Bibliographical note

Funding Information:
This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We acknowledge National Instrumentation Center for Environmental Management (NICEM) for providing opportunity for measurement of NMR.

Keywords

Apoptosis
Conjugated linoleic acid (CLA)
Pluronic F127
Polymer conjugation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2007.03.007

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title = "Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells",

abstract = "This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.",

keywords = "Apoptosis, Conjugated linoleic acid (CLA), Pluronic F127, Polymer conjugation",

author = "Guo, {Ding Ding} and Moon, {Hyun Seuk} and Rohidas Arote and Seo, {Ji Hye} and Quan, {Ji Shan} and Choi, {Yun Jaie} and Cho, {Chong Su}",

note = "Funding Information: This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We acknowledge National Instrumentation Center for Environmental Management (NICEM) for providing opportunity for measurement of NMR.",

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doi = "10.1016/j.canlet.2007.03.007",

language = "English",

volume = "254",

pages = "244--254",

journal = "Cancer letters",

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T1 - Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells

AU - Guo, Ding Ding

AU - Moon, Hyun Seuk

AU - Arote, Rohidas

AU - Seo, Ji Hye

AU - Quan, Ji Shan

AU - Choi, Yun Jaie

AU - Cho, Chong Su

N1 - Funding Information: This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We acknowledge National Instrumentation Center for Environmental Management (NICEM) for providing opportunity for measurement of NMR.

PY - 2007/9/8

Y1 - 2007/9/8

N2 - This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.

AB - This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.

KW - Apoptosis

KW - Conjugated linoleic acid (CLA)

KW - Pluronic F127

KW - Polymer conjugation

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U2 - 10.1016/j.canlet.2007.03.007

DO - 10.1016/j.canlet.2007.03.007

M3 - Article

C2 - 17482349

AN - SCOPUS:34547224113

SN - 0304-3835

VL - 254

SP - 244

EP - 254

JO - Cancer letters

JF - Cancer letters

IS - 2

ER -

Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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