Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch

Yi Xuan Li; Yeon Ji Kim; Chagam Koteswara Reddy; Sung Joon Lee; Seung Taik Lim

doi:10.1016/j.carbpol.2019.04.082

Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch

Yi Xuan Li
, Yeon Ji Kim
, Chagam Koteswara Reddy
, Sung Joon Lee
, Seung Taik Lim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Carbohydrate Polymers
Volume	219
DOIs	https://doi.org/10.1016/j.carbpol.2019.04.082
Publication status	Published - 2019 Sept 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP No. 2017R1A2A2A05001120 ); and the Scientific Research Foundation of Jiangsu University of Science and Technology (Grant No. 1182931805 ). The authors thank Jongyeop Seok for the assistance with the animal experiments.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Alpha-lipoic acid
Bioavailability
Cellular absorption
Encapsulation
Octenylsuccinylated high-amylose starch
V-type complex

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2019.04.082

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title = "Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch",

abstract = "An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40\%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50\% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.",

keywords = "Alpha-lipoic acid, Bioavailability, Cellular absorption, Encapsulation, Octenylsuccinylated high-amylose starch, V-type complex",

author = "Li, \{Yi Xuan\} and Kim, \{Yeon Ji\} and Reddy, \{Chagam Koteswara\} and Lee, \{Sung Joon\} and Lim, \{Seung Taik\}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP No. 2017R1A2A2A05001120 ); and the Scientific Research Foundation of Jiangsu University of Science and Technology (Grant No. 1182931805 ). The authors thank Jongyeop Seok for the assistance with the animal experiments. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

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doi = "10.1016/j.carbpol.2019.04.082",

language = "English",

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journal = "Carbohydrate Polymers",

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AU - Li, Yi Xuan

AU - Kim, Yeon Ji

AU - Reddy, Chagam Koteswara

AU - Lee, Sung Joon

AU - Lim, Seung Taik

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP No. 2017R1A2A2A05001120 ); and the Scientific Research Foundation of Jiangsu University of Science and Technology (Grant No. 1182931805 ). The authors thank Jongyeop Seok for the assistance with the animal experiments. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/9/1

Y1 - 2019/9/1

N2 - An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.

AB - An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.

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KW - Bioavailability

KW - Cellular absorption

KW - Encapsulation

KW - Octenylsuccinylated high-amylose starch

KW - V-type complex

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ER -

Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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