Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive

Young Ju Lee, Ho Sung Son, Gyeong Bok Jung, Ji Hye Kim, Samjin Choi, Gi Ja Lee, Hun Kuk Park

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods according to the ISO-10993 cytotoxicity test for medical devices. The PACA/PLLA have similar or even better biocompatibility than those of commercially available cyanoacrylate (CA)-based TAs such as Dermabond® and Histoacryl®. The PACA/PLLA were not different from those exposed to Dermabond® and Histoacryl® in Raman spectra when biochemical changes of protein and DNA/RNA underlying during cell death were compared utilizing Raman spectroscopy. Histological analysis revealed that incised dermal tissues of rats treated with PACA/PLLA showed less inflammatory signs and enhanced collagen formation compared to those treated with Dermabond® or Histoacryl®. Of note, tissues treated with PACA/PLLA were stronger in the tensile strength compared to those treated with the commercially available TAs. Therefore, taking all the results into consideration, the PACA/PLLA we created might be a clinically useful TA for treating dermal wounds.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalMaterials Science and Engineering C
Publication statusPublished - 2015 Jun 1
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a grant from Kyung Hee University in 2013 ( KHU-20131086 ).

Publisher Copyright:
© 2015 Elsevier B.V.


  • Biocompatibility
  • Bond strength
  • Mechanical strength
  • Pre-polymerized allyl 2-cyanoacrylate (PACA)/poly L-lactic acid (PLLA)
  • Tissue adhesive
  • Wound healing

ASJC Scopus subject areas

  • Medicine(all)


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