Enhanced IL-18 expression in common skin tumors

Hyunjeong Park, Daegyoo Byun, Tae S. Kim, Young I. Kim, Jae S. Kang, Eun S. Hahm, Seong H. Kim, Wang J. Lee, Hyun K. Song, Do Y. Yoon, Chang J. Kang, Changnam Lee, Dong Houh, Hyungok Kim, Baikkee Cho, Youngsill Kim, Yool H. Yang, Kyung H. Min, Dae H. Cho

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalImmunology Letters
Issue number3
Publication statusPublished - 2001 Dec 3
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project (HMP-00-B-20800-0079), Ministry of Health & Welfare, Republic of Korea and Holy Family Hospital.


  • IL-18
  • Skin tumors
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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