Enhanced mechanical and biological characteristics of PLLA composites through surface grafting of oligolactide on magnesium hydroxide nanoparticles

Eun Young Kang, Sung Bin Park, Bogyu Choi, Seung Woon Baek, Kyoung Won Ko, Won Kyu Rhim, Wooram Park, Ik Hwan Kim, Dong Keun Han

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Poly(l-lactic acid) (PLLA) is a biocompatible and biodegradable polymer that has received much attention as a biomedical material. However, PLLA also produces by-products that acidify the surrounding tissues during in vivo degradation, which induces inflammatory responses. To overcome these problems, magnesium hydroxide nanoparticles (nano-magnesium hydroxide; nMH) were added to the PLLA matrix as a bioactive filler that can suppress inflammatory responses by neutralizing the acidified environment caused by the degradation of PLLA. Despite the advantages of nMH, the strong cohesion of these nanoparticles toward each other makes it difficult to manufacture a polymer matrix containing homogeneous nanoparticles through thermal processing. Here, we prepared two types of surface-modified nMH with oligolactide (ODLLA) utilizing grafting to (GT) and grafting from (GF) strategies to improve the mechanical and biological characteristics of the organic-inorganic hybrid composite. The incorporation of surface-modified nMH not only enhanced mechanical properties, such as Young's modulus, but also improved homogeneity of magnesium hydroxide particles in the PLLA matrix due to the increase in interfacial interaction. Additionally, the PLLA composites with surface-modified nMH exhibited reduced bulk erosion during hydrolytic degradation with lower cytotoxicity and immunogenicity. Hemocompatibility tests on the PLLA composites with nMH showed a higher albumin to fibrinogen ratio (AFR) and a lower influence of platelet activation, when compared with unmodified control samples. Taken all together, the surface-modified nMH could be seen to successfully improve the physical and biological characteristics of polymer composites. We believe this technology has great potential for the development of hybrid nanocomposites for biomedical devices, including cardiovascular implants.

Original languageEnglish
Pages (from-to)2018-2030
Number of pages13
JournalBiomaterials Science
Volume8
Issue number7
DOIs
Publication statusPublished - 2020 Apr 7

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program (2020R1A2B5B03002344) and Bio&Medical Technology Development Program (2018M3A9E2024579) through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT), Core Materials Technology Development Program (10048019) founded by the Ministry of Trade, Industry and Energy (MOTIE), and Basic Science Research Program (2017R1A6A3A04012362) through the National Research Founded by the Ministry of Education, Republic of Korea.

Publisher Copyright:
© 2020 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Biomedical Engineering
  • General Materials Science

Fingerprint

Dive into the research topics of 'Enhanced mechanical and biological characteristics of PLLA composites through surface grafting of oligolactide on magnesium hydroxide nanoparticles'. Together they form a unique fingerprint.

Cite this