Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting

Hyo Sung Jung, Jiyou Han, Jae Hong Lee, Ji Ha Lee, Jong Min Choi, Hee Seok Kweon, Ji Hye Han, Jong-Hoon Kim, Kyung Min Byun, Jong Hwa Jung, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)


Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.

Original languageEnglish
Pages (from-to)3017-3023
Number of pages7
JournalJournal of the American Chemical Society
Issue number8
Publication statusPublished - 2015 Mar 4

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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