With the aim to establish a novel nanocarrier system with higher payload and higher photo-protection for deltamethrin (active ingredient) compared to solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) were prepared by combining hot homogenization and sonication with different ratios of corn oil (liquid lipid) and beeswax (solid lipid). Compared to SLN, the incorporation of corn oil gave a higher payload, slower release rate and higher photo-protection for deltamethrin. Particularly, compared to beeswax solid lipid nanoparticles (BSLN), NLC gave a higher payload (approximately 1.79 times) with a high encapsulation efficiency (83.6), higher photo-protection in direct photolysis (1.8 times) after 12h exposure of ultraviolet light (UV) and in indirect photolysis (1.37 times) after 2h exposure of UV in 2 (v/v) acetone solution used as a photosensitizer. This study demonstrated that novel nanocarrier possesses a wide range of applicability in protecting photo-labile compounds for the crop, food and pharmaceutical industries.
Bibliographical noteFunding Information:
This study was partly supported by Grant of Kyung-Nong Company and Korea University, Republic of Korea.
- Corn oil
- Nanostructured lipid carriers
ASJC Scopus subject areas
- Pharmaceutical Science
- Physical and Theoretical Chemistry
- Organic Chemistry
- Colloid and Surface Chemistry