Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

Hae Won Kim; Yoon Jung Noh; Young Hag Koh; Hyoun Ee Kim

doi:10.1023/A:1025638811361

Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

Hae Won Kim, Yoon Jung Noh, Young Hag Koh, Hyoun Ee Kim

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al₂O₃) were successfully fabricated without applying pressure at 1400°C for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than ∼ 2-4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days.

Original language	English
Pages (from-to)	899-904
Number of pages	6
Journal	Journal of Materials Science: Materials in Medicine
Volume	14
Issue number	10
DOIs	https://doi.org/10.1023/A:1025638811361
Publication status	Published - 2003 Oct 1
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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title = "Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering",

abstract = "Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al2O3) were successfully fabricated without applying pressure at 1400°C for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than ∼ 2-4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days.",

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AU - Kim, Hae Won

AU - Noh, Yoon Jung

AU - Koh, Young Hag

AU - Kim, Hyoun Ee

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Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

Abstract

Bibliographical note

ASJC Scopus subject areas

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